Enhancement of CTL response induced by a viral peptide using cationized BSA, a Th1-stimulating adjuvant.

@article{Vasilakos1994EnhancementOC,
  title={Enhancement of CTL response induced by a viral peptide using cationized BSA, a Th1-stimulating adjuvant.},
  author={John P Vasilakos and J. Gabriel Michael},
  journal={Viral immunology},
  year={1994},
  volume={7 4},
  pages={
          179-88
        }
}
We have recently shown that it is possible to activate cytotoxic T cells (CTL) in vivo with HSV-1 glycoprotein B H-2Kb-restricted peptide (gB peptide) independent of CD4+ T cell help. Here we report that the gB peptide-specific CTL response is significantly enhanced when mice are immunized with a mixture of gB peptide and cationized BSA (cBSA). The latter molecule is a positively charged form of the native BSA molecule that stimulates CD4+ T cells to produce cytokines characteristic of Th1… CONTINUE READING