Enhancement of CIITA transcriptional function by ubiquitin

  title={Enhancement of CIITA transcriptional function by ubiquitin},
  author={Susanna F Greer and Eleni Zika and Brian Conti and Xin-Sheng Zhu and Jenny P-Y Ting},
  journal={Nature Immunology},
Although increasing evidence indicates that there is a direct link between ubiquitination and mono-ubiquitination and transcription in yeast, this link has not been demonstrated in higher eukaryotes. Here we show that the major histocompatibility complex (MHC) class II transactivator (CIITA), which is required for expression of genes encoding MHC class II molecules, is ubiquitinated. This ubiquitination enhanced the association of CIITA with both MHC class II transcription factors and the MHC… CONTINUE READING


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