Enhancement of Berberine Production in Suspension Cultures of Coptis japonica by Gibberellic Acid Treatment

  title={Enhancement of Berberine Production in Suspension Cultures of Coptis japonica by Gibberellic Acid Treatment},
  author={Yasuhiro Hara and Toshihiro Yoshioka and Teijiro Morimoto and Yasuhiro Fujita and Yasuyuki Yamada},
  journal={Journal of Plant Physiology},
Summary The production of berberine by cell cultures of Coptis japonica was enhanced by the addition of gibberellic acid (GA3 10 −8 –10 −5 M) to the medium, particularly in the early stages of the culture period. After 14 days of culture the berberine yield of GA3 treated cells (10 −8 M) was 1660 mg·1 −1 suspension, controls 1230 mg·l −1 . Also, the addition of gibberellic acid suppressed the starch synthesis in the late exponential growth phase. Furthermore, the addition of gibberellic acid… Expand
17 Citations
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