Enhancement of Autophagy by Histone Deacetylase Inhibitor Trichostatin A Ameliorates Neuronal Apoptosis After Subarachnoid Hemorrhage in Rats

Abstract

Trichostatin A (TSA), a pan-histone deacetylase inhibitor, exerts multiple neuroprotective properties. This study aims to examine whether TSA could enhance autophagy, thereby reduce neuronal apoptosis and ultimately attenuate early brain injury (EBI) following subarachnoid hemorrhage (SAH). SAH was performed through endovascular perforation method, and… (More)
DOI: 10.1007/s12035-014-8986-0

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Cite this paper

@article{Shao2014EnhancementOA, title={Enhancement of Autophagy by Histone Deacetylase Inhibitor Trichostatin A Ameliorates Neuronal Apoptosis After Subarachnoid Hemorrhage in Rats}, author={Anwen Shao and Zhen Wang and Haijian Wu and Xiao Dong and Yong Li and Sheng Tu and Junjia Tang and Mingfei Zhao and Jianmin Zhang and Yuan Hong}, journal={Molecular Neurobiology}, year={2014}, volume={53}, pages={18-27} }