Enhancement of Antitumor Immunity by CTLA-4 Blockade

@article{Leach1996EnhancementOA,
  title={Enhancement of Antitumor Immunity by CTLA-4 Blockade},
  author={Dana R. Leach and Matthew F. Krummel and James P. Allison},
  journal={Science},
  year={1996},
  volume={271},
  pages={1734 - 1736}
}
One reason for the poor immunogenicity of many tumors may be that they cannot provide signals for CD28-mediated costimulation necessary to fully activate T cells. [] Key Result Here, in vivo administration of antibodies to CTLA-4 resulted in the rejection of tumors, including preestablished tumors. Furthermore, this rejection resulted in immunity to a secondary exposure to tumor cells. These results suggest that blockade of the inhibitory effects of CTLA-4 can allow for, and potentiate, effective immune…
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Newly emerging data suggest that inhibitory signals mediated by CTLA-4 not only can determine whether T cells become activated, but also can play a role in regulating the clonal representation in a polyclonal response.
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