• DOI:10.1126/science.271.5256.1734
Corpus ID: 7215817

Enhancement of Antitumor Immunity by CTLA-4 Blockade

@article{Leach1996EnhancementOA,
  title={Enhancement of Antitumor Immunity by CTLA-4 Blockade},
  author={D. Leach and M. Krummel and J. Allison},
  journal={Science},
  year={1996},
  volume={271},
  pages={1734 - 1736}
}

D. Leach, M. Krummel, J. Allison

Published 1996

Biology, Medicine

Science

One reason for the poor immunogenicity of many tumors may be that they cannot provide signals for CD28-mediated costimulation necessary to fully activate T cells. [...] Key Result Here, in vivo administration of antibodies to CTLA-4 resulted in the rejection of tumors, including preestablished tumors. Furthermore, this rejection resulted in immunity to a secondary exposure to tumor cells. These results suggest that blockade of the inhibitory effects of CTLA-4 can allow for, and potentiate, effective immune…Expand Abstract

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