Enhancement of Antigen-specific functional responses by neutrophils from allergic patients

  title={Enhancement of Antigen-specific functional responses by neutrophils from allergic patients},
  author={Javier Monteseir{\'i}n and Marlene Camacho and Rosa Monta{\~n}o and E Llamas and Manuel Conde and Modesto Carballo and Pedro Guardia and Jos{\'e} Conde and Francisco Sobrino},
  journal={The Journal of Experimental Medicine},
  pages={2571 - 2579}
It has been demonstrated that neutrophils from healthy donors or from patients with inflammatory disorders can bind immunoglobulin (Ig) E proteins through binding to Mac-2/epsilon bp. Functional responses to allergens were assessed by measuring the respiratory burst and intracellular Ca2+ levels, and binding of allergens to neutrophils was assessed by flow cytometry analysis and fluorescence microscopy. In this article, we demonstrate that neutrophils sensitized to specific allergens (from… CONTINUE READING

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