Enhancement of Activity of la , 25-Dihydroxyvitamin D 3 for Growth Inhibition and Differentiation Induction of Human Myelomonocytic Leukemia Cells by Tretinoin Tocoferil , an a-Tocopherol Ester of All-trans Retinoic Acid

@inproceedings{Makishima2002EnhancementOA,
  title={Enhancement of Activity of la , 25-Dihydroxyvitamin D 3 for Growth Inhibition and Differentiation Induction of Human Myelomonocytic Leukemia Cells by Tretinoin Tocoferil , an a-Tocopherol Ester of All-trans Retinoic Acid},
  author={By Makoto Makishima and Yasuhiro Kanatani and Yuri Yamamoto-Yamaguchi and Yoshio Honma},
  year={2002}
}
Tretinoin tocoferil is an a-tocopherol ester of all-trans retinoic acid (RA) and safely used in the treatment of skin ulcer. Tretinoin tocoferil inhibited proliferation of human promyelocytic leukemia HL-60 cells and induced granulocytic differentiation of the cells, but less than RA. a-Tocopherol did not affect differentiation of HL-60 cells, but at high concentrations enhanced its nitroblue tetrazolium (NBT)-reducing activity and expression of surface antigen CD11 b, which are markers of… CONTINUE READING