Enhancement of ALA-PDT damage by IR-induced hyperthermia on a colon carcinoma model.

@article{Orenstein1999EnhancementOA,
  title={Enhancement of ALA-PDT damage by IR-induced hyperthermia on a colon carcinoma model.},
  author={Arie Orenstein and Genady Kostenich and Y. Kopolovic and T. G. Babushkina and Zvi Malik},
  journal={Photochemistry and photobiology},
  year={1999},
  volume={69 6},
  pages={
          703-7
        }
}
The interaction of photodynamic therapy (PDT) with 5-aminolevulinic acid (ALA) and hyperthermia is not well understood. In the present study, significant enhancement of tumor damage was observed after simultaneous application of ALA-PDT and IR-induced hyperthermia using a broad-band incoherent light source. One hour after systemic administration of ALA at a dose of 200 mg/kg, subcutaneously transplanted C26 colon carcinoma tumors were irradiated with two bands of the VersaLight system, red (R… CONTINUE READING
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