Enhancement of 3,4-methylenedioxymethamphetamine neurotoxicity by the energy inhibitor malonate.

@article{Nixdorf2001EnhancementO3,
  title={Enhancement of 3,4-methylenedioxymethamphetamine neurotoxicity by the energy inhibitor malonate.},
  author={Wendy Nixdorf and Kristan B. Burrows and Gary A. Gudelsky and Bryan K. Yamamoto},
  journal={Journal of neurochemistry},
  year={2001},
  volume={77 2},
  pages={
          647-54
        }
}
The acute and long-term effects of the local perfusion of 3,4-methylenedioxymethamphetamine (MDMA) and the interaction with the mitochondrial inhibitor malonate (MAL) were examined in the rat striatum. MDMA, MAL or the combination of MAL with MDMA was reverse dialyzed into the striatum for 8 h via a microdialysis probe while extracellular dopamine (DA) and serotonin (5-HT) were measured. One week later, tissue immediately surrounding the probe was assayed for DA and 5-HT tissue content. Local… CONTINUE READING

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