Enhancement of γ-aminobutyric acid production in recombinant Corynebacterium glutamicum by co-expressing two glutamate decarboxylase genes from Lactobacillus brevis

@article{Shi2013EnhancementO,
  title={Enhancement of γ-aminobutyric acid production in recombinant Corynebacterium glutamicum by co-expressing two glutamate decarboxylase genes from Lactobacillus brevis},
  author={Feng Shi and Junjun Jiang and Yongfu Li and Youxin Li and Yilong Xie},
  journal={Journal of Industrial Microbiology & Biotechnology},
  year={2013},
  volume={40},
  pages={1285-1296}
}
γ-Aminobutyric acid (GABA), a non-protein amino acid, is a bioactive component in the food, feed and pharmaceutical fields. To establish an effective single-step production system for GABA, a recombinant Corynebacterium glutamicum strain co-expressing two glutamate decarboxylase (GAD) genes (gadB1 and gadB2) derived from Lactobacillus brevis Lb85 was constructed. Compared with the GABA production of the gadB1 or gadB2 single-expressing strains, GABA production by the gadB1–gadB2 co-expressing… CONTINUE READING
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