Enhancement of γ‐Aminobutyric Acid Binding by Quazepam, a Benzodiazepine Derivative with Preferential Affinity for Type I Benzodiazepine Receptors

@article{Corda1986EnhancementO,
  title={Enhancement of $\gamma$‐Aminobutyric Acid Binding by Quazepam, a Benzodiazepine Derivative with Preferential Affinity for Type I Benzodiazepine Receptors},
  author={M. G. Corda and Enrico Sanna and A Concas and Osvaldo Giorgi and Ennio Ongini and Valeria Marina Nurchi and Teresa Pintori and Guido Crisponi and Giovanni Biggio},
  journal={Journal of Neurochemistry},
  year={1986},
  volume={47}
}
Abstract: We evaluated the effect of the two N‐trifluoroethyl benzodiazepines, quazepam and its 2‐oxo metabolite SCH 15725, which possess preferential affinity for type I benzodiazepine recognition sites, on the binding of [3H]γ‐aminobutyric acid ([3H]GABA) to rat brain membrane preparations. The study also included compounds such as diazepam and N‐desalkyl‐2‐oxoquazepam (SCH 17514), which have equal affinity for the type I and type II receptor subtypes. Binding of [3H]GABA was studied in… 
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