Enhancement in vitro of the low interferon-gamma production of leukocytes from human newborn infants.

@article{McKenzie1993EnhancementIV,
  title={Enhancement in vitro of the low interferon-gamma production of leukocytes from human newborn infants.},
  author={Steven E. McKenzie and James Bradford Kline and Steven D. Douglas and Richard A. Polin},
  journal={Journal of leukocyte biology},
  year={1993},
  volume={53 6},
  pages={691-6}
}
Interferon-gamma (IFN-gamma), a lymphokine produced by lymphocytes with the help of monocytes, is essential for host resistance to intracellular pathogens. Leukocytes from normal term newborn infants cannot produce IFN-gamma in vitro in response to stimulation by antigen or mitogens in vitro or in vivo. We investigated the production of IFN-gamma in vitro using endotoxin from Salmonella typhimurium as a stimulus. In contrast to those from adults, mononuclear cells derived from the cord blood of… CONTINUE READING