Enhancement effects of (R) and (S) enantiomers and the racemate of a model enhancer on permeation of theophylline through human skin

@article{Vvrov2002EnhancementEO,
  title={Enhancement effects of (R) and (S) enantiomers and the racemate of a model enhancer on permeation of theophylline through human skin},
  author={Kateřina V{\'a}vrov{\'a} and Alexandr Hrab{\'a}lek and Pavel Dole{\vz}al},
  journal={Archives of Dermatological Research},
  year={2002},
  volume={294},
  pages={383-385}
}
The conformation of a permeation enhancer, given their mechanism of action, could influence its enhancing properties, since the stratum corneum components form essentially a chiral environment. The racemate and both enantiomers of 6-aminohexanoic acid 2-octylester as model enhancers with one chiral center were synthesized and their ability to enhance in vitro theophylline permeation through human skin was tested. The MTMT concept could not be applied in this study (the melting points of the… CONTINUE READING