Enhancement effect of resveratrol on the intestinal absorption of bestatin by regulating PEPT1, MDR1 and MRP2 in vivo and in vitro.

@article{Jia2015EnhancementEO,
  title={Enhancement effect of resveratrol on the intestinal absorption of bestatin by regulating PEPT1, MDR1 and MRP2 in vivo and in vitro.},
  author={Yongming Jia and Zhihao Liu and Xiaokui Huo and Changyuan Wang and Qiang Meng and Qi Liu and Huijun Sun and Pengyuan Sun and Xiaobo Yang and Xiaohong Shu and Kexin Liu},
  journal={International journal of pharmaceutics},
  year={2015},
  volume={495 1},
  pages={588-598}
}
The purpose of present study was to assess the enhancing effect of resveratrol (Res) on the absorption of bestatin and clarify the related molecular mechanism. Res facilitated bestatin absorption by down-regulating both protein and gene levels of multidrug resistance 1 (Mdr1) and Multidrug resistance-associated protein 2 (Mrp2), and up-regulating… CONTINUE READING