Enhancement by tumor necrosis factor alpha of dengue virus-induced endothelial cell production of reactive nitrogen and oxygen species is key to hemorrhage development.

@article{Yen2008EnhancementBT,
  title={Enhancement by tumor necrosis factor alpha of dengue virus-induced endothelial cell production of reactive nitrogen and oxygen species is key to hemorrhage development.},
  author={Y E Yen and Hsuen-Chin Chen and Yang-Ding Lin and C. -S. Shieh and Betty A Wu-Hsieh},
  journal={Journal of virology},
  year={2008},
  volume={82 24},
  pages={12312-24}
}
Hemorrhage is a severe manifestation of dengue disease. Virus strain and host immune response have been implicated as the risk factors for hemorrhage development. To delineate the complex interplay between the virus and the host, we established a dengue hemorrhage model in immune-competent mice. Mice inoculated intradermally with dengue virus develop hemorrhage within 3 days. In the present study, we showed by the presence of NS1 antigen and viral nuclei acid that dengue virus actively infects… CONTINUE READING

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