Enhancement by serotonin of GABA-mediated inhibitory synaptic currents in rat cerebellar Purkinje cells.

@article{Mitoma1994EnhancementBS,
  title={Enhancement by serotonin of GABA-mediated inhibitory synaptic currents in rat cerebellar Purkinje cells.},
  author={Hiroshi Mitoma and Toshiyuki Kobayashi and S Y Song and Shiro Konishi},
  journal={Neuroscience letters},
  year={1994},
  volume={173 1-2},
  pages={127-30}
}
The actions of serotonin (5-HT) on synaptic responses in Purkinje cells were examined using the whole-cell voltage-clamp recording from thin slices of the rat cerebellum. Focal stimulation within the molecular layer elicited synaptic responses: (1) inhibitory postsynaptic currents (IPSCs) that were completely blocked by bicuculline; (2) excitatory postsynaptic currents (EPSCs) that were antagonized by CNQX; and (3) combination of IPSC and EPSC. Application of 5-HT (3-30 microM) increased the… CONTINUE READING
11 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 11 extracted citations

Similar Papers

Loading similar papers…