Enhancement by food of canrenone bioavailability from spironolactone

@article{Melander1977EnhancementBF,
  title={Enhancement by food of canrenone bioavailability from spironolactone},
  author={Arne Melander and K. Danielson and B. Seherst{\'e}n and Thomas Thulin and Erik W{\aa}hlin},
  journal={Clinical Pharmacology \& Therapeutics},
  year={1977},
  volume={22}
}
The influence of food intake on the bioavailabiliry of canrenone, the major and active metabolite of spironolactone, was explored in 8 healthy male volunteers. Spironolactone was administered as a single oral dose of 100 mg, both in the fasting state and together wirh a srandardized breakfast. Numerous venous blood sampies were raken from 30 min to 96 hr after ingestion of the drug, and the plasma concentrations of eanrenone were determined by speetrofluorometry. The results indicxate that more… Expand
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SummaryThe pharmacokinetics of canrenone and ‘total metabolites’ after base hydrolysis was studied in eight young volunteers following single and multiple dose oral administration of spironolactone.Expand
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THE METABOLISM AND BIOPHARMACEUTICS OF SPIRONOLACTONE IN MAN
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It was demonstrated that after a single oral dose of spironolactone, 7 alpha-thiomethylspirolactone is the main metabolite and that unchanged spironlactone reaches maximum serum concentrations which are in the same order of magnitude as canrenone. Expand
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References

SHOWING 1-10 OF 21 REFERENCES
Reduction of isoniazid bioavailability in normal men by concomitant intake of food.
TLDR
The observations indicate that both the peak concentration and the total amount of INH absorbed are greatly reduced when the drug is ingested together with food, and it is recommended that, in the treatment of tuberculosis with INH, the drug should be given on an empty stomach. Expand
Bioavailability of propylthiouracil: Interindividual variation and influence of food intake.
TLDR
The observations indicate that the amount of PTU absorbed is subject to a large interindividual variation, and that concomitant food intake may exert a minor and non-systematic influence on PTU absorption. Expand
On the influence of concomitant food intake on sulfonamide bioavailability.
TLDR
The influence of food intake on the bioavailability of a frequently used short-acting sulfonamide, sulfaisomidine (Elkosin), has been examined in eight healthy volunteers and it is indicated that concomitant food intake alters neither absorption rate, peak concentration, time to reach peak Concentration, elimination rate, nor total amount of sulf onamide reaching the general circulation. Expand
Pharmacokinetics of spironolactone, canrenone and canrenoate-K in humans.
TLDR
Equimolar doses of spironolactone (I), canrenone (II) and canrenoate-K (III) were given orally and III intravenously to 16 patients and a major part of the metabolism remains unknown. Expand
Effect of food on nitrofurantoin absorption
TLDR
There was an increase in the duration of therapeutic urinary concentrations of nitrofurantoin when either form was taken with food, and the practice of using fasting subiects in bioavailability studies of drug products normally administered with food is questionable. Expand
Pharmacokinetics of carbamazepine in normal man
TLDR
The time course of side effects could not be correlated with serum carbamazepine levels, suggesting that metabolites contributed to side effects, and absorption and elimination half‐lives appear to be independent of dose. Expand
A fluorimetric method for the determination of a major spironolactone (Aldactone) metabolite in human plasma.
  • N. Gochman, C. Gantt
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental therapeutics
  • 1962
TLDR
Data obtained by fluorescence characteristics and paper chromatography indicate that the metabolite is the de-thioacetylated derivative, 3-(3-oxo-17β-hydroxy-4,6-androstadien-17α-yl) propionic acid γ-lactone. Expand
Enhancement of hydralazine bioavai1ability by food
  • CUN. PHARMACOL. THER
  • 1977
Enhancement of hydralazine bioavai1ability by food, CUN
  • PHARMACOL. THER
  • 1977
Spironolactone . 11 . Bioavailability , CUN
  • . PHARMACOL . THER .
  • 1976
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