Enhancement by a serum factor of immunoglobulin-mediated histamine release from human leukocytes.


When serum was fractionated on Sephadex G-200, the material eluted in the second and thir major peaks had a very pronounced capacity to enhance IgE- as well as IgG-mediated histamine release from the leukocytes of both normal and allergic donors. Unseparated serum on the other hand had a low capacity to stimulate anti-IgE-induced histamine release. Besides… (More)


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