Enhancement and suppression of signaling by the conserved tail of IgG memory–type B cell antigen receptors

@article{Horikawa2007EnhancementAS,
  title={Enhancement and suppression of signaling by the conserved tail of IgG memory–type B cell antigen receptors},
  author={Keisuke Horikawa and Stephen W. Martin and Sarah L. Pogue and Karlee L Silver and Kaiman Peng and Kiyoshi Takatsu and Christopher C. Goodnow},
  journal={The Journal of Experimental Medicine},
  year={2007},
  volume={204},
  pages={759 - 769}
}
Immunological memory is characterized by heightened immunoglobulin (Ig) G antibody production caused in part by enhanced plasma cell formation conferred by conserved transmembrane and cytoplasmic segments in isotype-switched IgG B cell receptors. We tested the hypothesis that the IgG tail enhances intracellular B cell antigen receptor (BCR) signaling responses to antigen by analyzing B cells from Ig transgenic mice with IgM receptors or chimeric IgMG receptors containing the IgG tail segment… CONTINUE READING
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