Enhancement and inhibition of apomorphine-induced sensitization in rats exposed to immobilization stress: Relationship with adaptation to stress

@article{Haleem2013EnhancementAI,
  title={Enhancement and inhibition of apomorphine-induced sensitization in rats exposed to immobilization stress: Relationship with adaptation to stress},
  author={Darakhshan Jabeen Haleem and Huma Ikram and Saida Haider and Tahira Parveen and Muhammad Mahmoud Abdul Haleem},
  journal={Pharmacology Biochemistry and Behavior},
  year={2013},
  volume={112},
  pages={22-28}
}
Stress increases vulnerability to addiction while drugs of abuse impair coping responses and pre-dispose to depression. Pre-clinical research shows that stress exposure augments locomotor sensitization effects of drugs of abuse and impairs behavioral tolerance to repeated stress. The present study investigates relationship between behavioral tolerance to repeated immobilization stress and apomorphine-induced sensitization. Apomorphine was injected either before exposure or after the termination… CONTINUE READING

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