Enhancement and depression by inosine of the growth inhibitory action of 5-fluorouracil on cultured Jensen tumor cells.

@article{Beltz1983EnhancementAD,
  title={Enhancement and depression by inosine of the growth inhibitory action of 5-fluorouracil on cultured Jensen tumor cells.},
  author={Richard E Beltz and R N Waters and T J Hegarty},
  journal={Biochemical and biophysical research communications},
  year={1983},
  volume={112 1},
  pages={235-41}
}
Continuous exposure of Jensen tumor cells in vitro to 1 mM inosine following a 1 hr exposure to 5-fluorouracil resulted in a 5-fold potentiation of growth inhibition. This effect was abolished by the simultaneous presence of 1 mM cytidine and was attributable to altered metabolic processing of drug anabolites after the uptake of 5-fluorouracil had ceased… CONTINUE READING