Enhancement and Passive Acoustic Mapping of Cavitation from Fluorescently Tagged Magnetic Resonance-Visible Magnetic Microbubbles In Vivo.

@article{Crake2016EnhancementAP,
  title={Enhancement and Passive Acoustic Mapping of Cavitation from Fluorescently Tagged Magnetic Resonance-Visible Magnetic Microbubbles In Vivo.},
  author={Calum Crake and Joshua James Owen and Sean C Smart and Christian M Coviello and Constantin C Coussios and Robert C. Carlisle and Eleanor Stride},
  journal={Ultrasound in medicine & biology},
  year={2016},
  volume={42 12},
  pages={
          3022-3036
        }
}
Previous work has indicated the potential of magnetically functionalized microbubbles to localize and enhance cavitation activity under focused ultrasound exposure in vitro. The aim of this study was to investigate magnetic targeting of microbubbles for promotion of cavitation in vivo. Fluorescently labelled magnetic microbubbles were administered intravenously in a murine xenograft model. Cavitation was induced using a 0.5-MHz focused ultrasound transducer at peak negative focal pressures of 1… CONTINUE READING
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