Enhanced xylitol production through simultaneous co-utilization of cellobiose and xylose by engineered Saccharomyces cerevisiae.

@article{Oh2013EnhancedXP,
  title={Enhanced xylitol production through simultaneous co-utilization of cellobiose and xylose by engineered Saccharomyces cerevisiae.},
  author={Eun Joong Oh and Suk-Jin Ha and Soo Rin Kim and Won-Heong Lee and Jonathan M. Galazka and Jamie H. D. Cate and Yong-Su Jin},
  journal={Metabolic engineering},
  year={2013},
  volume={15},
  pages={226-34}
}
As Saccharomyces cerevisiae cannot utilize xylose as a carbon source, expression of XYL1 coding for xylose reductase (XR) from Scheffersomyces (Pichia) stipitis enabled production of xylitol from xylose with a high yield. However, insufficient supply of NAD(P)H for XR and inhibition of xylose uptake by glucose are identified as major constraints for achieving high xylitol productivity. To overcome these problems, we engineered S. cerevisiae capable of converting xylose into xylitol through… CONTINUE READING

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