Enhanced vulnerability of PARK6 patient skin fibroblasts to apoptosis induced by proteasomal stress.

@article{Klinkenberg2010EnhancedVO,
  title={Enhanced vulnerability of PARK6 patient skin fibroblasts to apoptosis induced by proteasomal stress.},
  author={Michael Klinkenberg and Nadia Thurow and Suzana Gispert and F. Ricciardi and Florian Eich and Jochen H. M. Prehn and Georg Auburger and Donat K{\"o}gel},
  journal={Neuroscience},
  year={2010},
  volume={166 2},
  pages={422-34}
}
Proteasomal dysfunction and apoptosis are major hallmarks in the pathophysiology of Parkinson's disease (PD). PARK6 which is caused by mutations in the mitochondrial protein kinase PINK1 is a rare autosomal-recessively inherited disorder mimicking the clinical picture of PD. To investigate the cytoprotective physiological function of PINK1, we used primary fibroblasts from three patients homozygous for G309D-PINK1 as well as SHEP neuroblastoma cells stably overexpressing GFP-tagged wild type… CONTINUE READING
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