Enhanced virulence of influenza A viruses with the haemagglutinin of the 1918 pandemic virus

@article{Kobasa2004EnhancedVO,
  title={Enhanced virulence of influenza A viruses with the haemagglutinin of the 1918 pandemic virus},
  author={Darwyn Kobasa and Ayato Takada and Kyoko Shinya and Masato Hatta and Peter Halfmann and Steven Theriault and Hiroshi Suzuki and Hidekazu Nishimura and Keiko Mitamura and Norio Sugaya and Taichi Usui and Takeomi Murata and Yasuko Maeda and Shinji Watanabe and Marulasiddappa Suresh and Takashi Suzuki and Yasuo Suzuki and Heinz Feldmann and Yoshihiro Kawaoka},
  journal={Nature},
  year={2004},
  volume={431},
  pages={703-707}
}
The ‘Spanish’ influenza pandemic of 1918–19 was the most devastating outbreak of infectious disease in recorded history. At least 20 million people died from their illness, which was characterized by an unusually severe and rapid clinical course. The complete sequencing of several genes of the 1918 influenza virus has made it possible to study the functions of the proteins encoded by these genes in viruses generated by reverse genetics, a technique that permits the generation of infectious… CONTINUE READING
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