Enhanced vasoconstrictor effect of endothelin in cerebral arteries from rats with subarachnoid haemorrhage.

@article{Alafaci1990EnhancedVE,
  title={Enhanced vasoconstrictor effect of endothelin in cerebral arteries from rats with subarachnoid haemorrhage.},
  author={Concetta Alafaci and Ingeborg Jansen and M. A. -R. Arbab and Yasuhiro Shiokawa and Niels Aage Svendgaard and Lars Edvinsson},
  journal={Acta physiologica Scandinavica},
  year={1990},
  volume={138 3},
  pages={317-9}
}
The contractile response to endothelin has been examined in cerebral arteries from rats subjected to a prior subarachnoid haemorrhage (SAH) and compared with saline-injected controls. Endothelin elicited concentration-dependent contractions of rat basilar artery segments. The endothelin-induced contractions were much stronger in the SAH compared to control animals, which suggests a role in the pathophysiology of cerebral vasospasm. 

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Endothelin and Its Inhibitors

Bkaily, Roger Corder, +4 authors Timothy D Warner
Handbook of Experimental Pharmacology • 2001

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