Enhanced vascular production of superoxide in OLETF rat after the onset of hyperglycemia.

@article{Kim2003EnhancedVP,
  title={Enhanced vascular production of superoxide in OLETF rat after the onset of hyperglycemia.},
  author={In Ju Kim and Yong Ki Kim and Seok Man Son and Ki Whan Hong and Chi Dae Kim},
  journal={Diabetes research and clinical practice},
  year={2003},
  volume={60 1},
  pages={11-8}
}
This study was aimed to characterize the vascular production of superoxide in Otsuka Long-Evans Tokushima Fatty (OLETF) rat, a model of type 2 diabetes. The nitroblue tetrazolium staining in the aorta from old (30 weeks) OLETF rat was more prominent than that of age-matched control (LETO) rat, which was significantly inhibited by diphenyleneiodonium (10 micromol/l), but not by inhibitors for other oxidases such as xanthine oxidase, mitochondrial oxidase, nitric oxide synthase, and… CONTINUE READING