Enhanced valine production in Corynebacterium glutamicum with defective H+-ATPase and C-terminal truncated acetohydroxyacid synthase.

@article{Wada2008EnhancedVP,
  title={Enhanced valine production in Corynebacterium glutamicum with defective H+-ATPase and C-terminal truncated acetohydroxyacid synthase.},
  author={Masaru Wada and Nowaki Hijikata and Ryo Aoki and Nobuchika Takesue and Atsushi Yokota},
  journal={Bioscience, biotechnology, and biochemistry},
  year={2008},
  volume={72 11},
  pages={2959-65}
}
We have reported increased glutamate production by a mutant of Corynebacterium glutamicum ATCC14067 (strain F172-8) with reduced H(+)-ATPase activity under biotin-limiting culture conditions (Aoki et al. Biosci. Biotechnol. Biochem., 69, 1466-1472 (2005)). In the present study, we examined valine production by an H(+)-ATPase-defective mutant of C. glutamicum. Using the double-crossover chromosome replacement technique, we constructed a newly defined H(+)-ATPase-defective mutant from ATCC13032… CONTINUE READING

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