Enhanced twin pregnancy detection within an open neural tube defect and Down syndrome screening protocol using free-beta hCG and AFP.

@article{Barnabei1995EnhancedTP,
  title={Enhanced twin pregnancy detection within an open neural tube defect and Down syndrome screening protocol using free-beta hCG and AFP.},
  author={Vanessa M. Barnabei and David A Krantz and James N Macri and John W. Larsen},
  journal={Prenatal diagnosis},
  year={1995},
  volume={15 12},
  pages={1131-4}
}
We have applied our multimarker approach of maternal serum alpha-fetoprotein (AFP) and free-beta human chorionic gonadotropin (hCG) for Down syndrome screening to multiple gestations to assess its efficacy for improved detection of twin and triplet pregnancies. This study matched 225 cases of twin pregnancy and 39 cases of triplet pregnancy each with ten singleton pregnancies based on gestational week, race, time to receive sample, time of year of sample, and geographical area. The ratios of… CONTINUE READING

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