Enhanced tumorigenicity of fibroblasts transformed with human herpesvirus 8 chemokine receptor vGPCR by successive passage in nude and immunocompetent mice

Abstract

The human herpes virus 8 (HHV-8)-encoded G protein-coupled chemokine receptor (vGPCR) has been implicated in the pathogenesis of Kaposi's sarcoma (KS), particularly because of its high constitutive signaling activity. Here, we used retroviral transduction to generate vGPCR-expressing 3T3 fibroblasts that are tumorigenic in nude mice, but as expected fail to… (More)
DOI: 10.1038/sj.onc.1210357

Topics

6 Figures and Tables

Cite this paper

@article{Thirunarayanan2007EnhancedTO, title={Enhanced tumorigenicity of fibroblasts transformed with human herpesvirus 8 chemokine receptor vGPCR by successive passage in nude and immunocompetent mice}, author={Nanthakumar Thirunarayanan and F Cifire and Iduna Fichtner and Stefan Posner and J Benga and P. Reiterer and Elizabeth Kremmer and Konrad Koelble and Melanie Lipp}, journal={Oncogene}, year={2007}, volume={26}, pages={5702-5712} }