Enhanced tumorigenic behavior of glioblastoma cells expressing a truncated epidermal growth factor receptor is mediated through the Ras-Shc-Grb2 pathway.

@article{Prigent1996EnhancedTB,
  title={Enhanced tumorigenic behavior of glioblastoma cells expressing a truncated epidermal growth factor receptor is mediated through the Ras-Shc-Grb2 pathway.},
  author={Sally A. Prigent and Motoo Nagane and H M Lin and Ivana Huvar and Gerry R. Boss and James R. Feramisco and Webster K Cavenee and H-J. Su Huang},
  journal={The Journal of biological chemistry},
  year={1996},
  volume={271 41},
  pages={25639-45}
}
A mutant epidermal growth factor receptor (DeltaEGFR) containing a deletion of 267 amino acids from the extracellular domain is common in human glioblastomas. We have previously shown that the mutant receptor fails to bind EGF, is constitutively phosphorylated, and confers upon U87MG glioblastoma cells expressing it (U87MG. DeltaEGFR), an increased ability to form tumors in mice. Here we demonstrate that the constitutively phosphorylated DeltaEGFR enhances growth of glioblastoma cells through… CONTINUE READING
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Truncated EGF Receptor Signals through Ras-Shc-Grb2 Pathway

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