Enhanced tumor delivery and antitumor activity in vivo of liposomal doxorubicin modified with MCF-7-specific phage fusion protein.

@article{Wang2014EnhancedTD,
  title={Enhanced tumor delivery and antitumor activity in vivo of liposomal doxorubicin modified with MCF-7-specific phage fusion protein.},
  author={Tao Wang and William Hartner and James W. Gillespie and Kulkarni P Praveen and Shenghong Yang and Leslie A Mei and Valery A. Petrenko and Vladimir Torchilin},
  journal={Nanomedicine : nanotechnology, biology, and medicine},
  year={2014},
  volume={10 2},
  pages={421-30}
}
UNLABELLED A novel strategy to improve the therapeutic index of chemotherapy has been developed by the integration of nanotechnology with phage technique. The objective of this study was to combine phage display, identifying tumor-targeting ligands, with a liposomal nanocarrier for targeted delivery of doxorubicin. Following the proof of concept in cell-based experiments, this study focused on in vivo assessment of antitumor activity and potential side-effects of phage fusion protein-modified… CONTINUE READING
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Landscape phage fusion protein-modified pharmaceutical nanocarriers for targeted and cytoplasmic delivery of chemotherapeutics to breast cancer cells in vitro and in vivo

  • T. Wang
  • Pharmaceutical Science Dissertations
  • 2012

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