Enhanced tumor accumulation of sub-2 nm gold nanoclusters for cancer radiation therapy.

@article{Zhang2014EnhancedTA,
  title={Enhanced tumor accumulation of sub-2 nm gold nanoclusters for cancer radiation therapy.},
  author={Xiaodong Zhang and Jie Chen and Zhentao Luo and Di Wu and Xiu Lian Shen and Sha-sha Song and Yuan-ming Sun and Pei-Xun Liu and Xiangui Zhao and Shuaidong Huo and Saijun Fan and Feiyue Fan and Xing-Jie Liang and Jianping Xie},
  journal={Advanced healthcare materials},
  year={2014},
  volume={3 1},
  pages={133-41}
}
A new type of metabolizable and efficient radiosensitizers for cancer radiotherapy is presented by combining ultrasmall Au nanoclusters (NCs, <2 nm) with biocompatible coating ligands (glutathione, GSH). The new nanoconstruct (GSH-coated Au25 NCs) inherits attractive features of both the Au core (strong radiosensitizing effect) and GSH shell (good biocompatibility). It can preferentially accumulate in tumor via the improved EPR effect, which leads to strong enhancement for cancer radiotherapy… CONTINUE READING
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