Enhanced tryptophan degradation in patients with ovarian carcinoma correlates with several serum soluble immune activation markers.

@article{SpernerUnterweger2011EnhancedTD,
  title={Enhanced tryptophan degradation in patients with ovarian carcinoma correlates with several serum soluble immune activation markers.},
  author={Barbara Sperner-Unterweger and Gabriele Neurauter and Martin Klieber and Katharina Kurz and Verena Meraner and Alain Zeimet and Dietmar Fuchs},
  journal={Immunobiology},
  year={2011},
  volume={216 3},
  pages={296-301}
}
Tryptophan-degrading enzyme indoleamine 2,3-dioxygenase (IDO) represents an antimicrobial and antitumoral immune effector mechanism, but IDO also suppresses T-cell responses and thus can cause immune system failure. Therefore, IDO was proposed as an immunoescape mechanism of tumor cells. Compared to healthy controls, accelerated tryptophan degradation was observed in the blood of 20 patients with ovarian carcinoma as is reflected by an increased kynurenine to tryptophan ratio (kyn/trp) which… CONTINUE READING

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