Enhanced tryptophan catabolism in the absence of the molecular adapter DAP12.

@article{Orabona2005EnhancedTC,
  title={Enhanced tryptophan catabolism in the absence of the molecular adapter DAP12.},
  author={Ciriana Orabona and Elena Tomasello and Francesca Fallarino and Roberta Bianchi and Claudia Volpi and Silvia Bellocchio and Luigina Romani and Maria Cristina Fioretti and Eric Vivier and Paolo Puccetti and Ursula Grohmann},
  journal={European journal of immunology},
  year={2005},
  volume={35 11},
  pages={3111-8}
}
DAP12 is an immunoreceptor tyrosine-based activation motif-bearing membrane adapter molecule expressed by different cell types. Although several receptors associate with DAP12 in murine dendritic cells (DC), the function of these receptors is as yet unknown. Here we report that splenic mature DC with DAP12 overexpression are characterized by an impaired tolerogenic potential. In contrast, inhibition of DAP12 function results in enhanced tolerogenesis and constitutive expression of… CONTINUE READING

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