Enhanced transfection efficiency and reduced cytotoxicity of novel lipid-polymer hybrid nanoplexes.

@article{Jain2013EnhancedTE,
  title={Enhanced transfection efficiency and reduced cytotoxicity of novel lipid-polymer hybrid nanoplexes.},
  author={Sanyog Jain and Sandeep Kumar and Ashish Kumar Agrawal and Kaushik Thanki and Uttam Chand Banerjee},
  journal={Molecular pharmaceutics},
  year={2013},
  volume={10 6},
  pages={2416-25}
}
The present study reports the development, characterization, and evaluation of novel polyelectrolytes stabilized lipoplexes as a nonviral vector for gene delivery. In order to achieve the advantage of both DOTAP (1,2-dioleoyl-3-trimethylammonium propane) and PEI (high transfection efficiency) a system was hypothesized in which DOTAP/phosphatidyl choline (PC) lipoplexes were electrostatically coated with anionic poly(acrylic acid) (PAA) and cationic polyethylenimine (PEI) alternatively to… CONTINUE READING

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