Enhanced transdermal delivery of indomethacin-loaded PLGA nanoparticles by iontophoresis.

@article{Tomoda2011EnhancedTD,
  title={Enhanced transdermal delivery of indomethacin-loaded PLGA nanoparticles by iontophoresis.},
  author={Keishiro Tomoda and Hiroto Terashima and Kenichi Suzuki and Toshio Inagi and Hiroshi Terada and K. Makino},
  journal={Colloids and surfaces. B, Biointerfaces},
  year={2011},
  volume={88 2},
  pages={706-10}
}
Nanoparticles effectively deliver therapeutic agent by penetrating into the skin. Indomethacin (IM) and coumarin-6 were loaded in PLGA nanoparticles with an average diameter of 100 nm. IM and coumarin-6 were chosen as a model drug and as a fluorescent marker, respectively. The surfaces of the nanoparticles were negatively charged. Permeability of IM-loaded… CONTINUE READING