Enhanced top-down characterization of histone post-translational modifications

  title={Enhanced top-down characterization of histone post-translational modifications},
  author={Zhixin Tian and Nikola Toli{\'c} and Rui Zhao and Ronald J. Moore and Shawna Hengel and Errol W. Robinson and David L Stenoien and Si Wu and Richard D. Smith and Ljiljana Pasa-Tolic},
  booktitle={Genome Biology},
Post-translational modifications (PTMs) of core histones work synergistically to fine tune chromatin structure and function, generating a so-called histone code that can be interpreted by a variety of chromatin interacting proteins. We report a novel online two-dimensional liquid chromatography-tandem mass spectrometry (2D LC-MS/MS) platform for high-throughput and sensitive characterization of histone PTMs at the intact protein level. The platform enables unambiguous identification of 708… CONTINUE READING
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