Enhanced tonic inhibition influences the hypnotic and amnestic actions of the intravenous anesthetics etomidate and propofol.

@article{Kretschmannova2013EnhancedTI,
  title={Enhanced tonic inhibition influences the hypnotic and amnestic actions of the intravenous anesthetics etomidate and propofol.},
  author={Karla Kretschmannova and Rochelle M Hines and Raquel Revilla-Sanchez and Miho Terunuma and Verena Tretter and Rachel Jurd and Max B Kelz and Stephen J. Moss and Paul A. Davies},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2013},
  volume={33 17},
  pages={7264-73}
}
Intravenous anesthetics exert a component of their actions via potentiating inhibitory neurotransmission mediated by γ-aminobutyric type-A receptors (GABAARs). Phasic and tonic inhibition is mediated by distinct populations of GABAARs, with the majority of phasic inhibition by subtypes composed of α1-3βγ2 subunits, whereas tonic inhibition is dependent on subtypes assembled from α4-6βδ subunits. To explore the contribution that these distinct forms of inhibition play in mediating intravenous… CONTINUE READING

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