Enhanced tolerance of Saccharomyces cerevisiae to multiple lignocellulose-derived inhibitors through modulation of spermidine contents.

@article{Kim2015EnhancedTO,
  title={Enhanced tolerance of Saccharomyces cerevisiae to multiple lignocellulose-derived inhibitors through modulation of spermidine contents.},
  author={Sun-Ki Kim and Yong-Su Jin and In-Geol Choi and Yong-Cheol Park and Jin-Ho Seo},
  journal={Metabolic engineering},
  year={2015},
  volume={29},
  pages={46-55}
}
Fermentation inhibitors present in lignocellulose hydrolysates are inevitable obstacles for achieving economic production of biofuels and biochemicals by industrial microorganisms. Here we show that spermidine (SPD) functions as a chemical elicitor for enhanced tolerance of Saccharomyces cerevisiae against major fermentation inhibitors. In addition, the feasibility of constructing an engineered S. cerevisiae strain capable of tolerating toxic levels of the major inhibitors without exogenous… CONTINUE READING
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