Enhanced tolerability of the 5-hydroxytryptophane challenge test combined with granisetron

@article{Jacobs2010EnhancedTO,
  title={Enhanced tolerability of the 5-hydroxytryptophane challenge test combined with granisetron},
  author={Gabriel E. Jacobs and Ingrid M C Kamerling and M. L. de Kam and Roel H Derijk and Johannes van Pelt and Frans G Zitman and Joop M A van Gerven},
  journal={Journal of Psychopharmacology},
  year={2010},
  volume={24},
  pages={65 - 72}
}
A recently developed oral serotonergic challenge test consisting of 5-Hydroxytryptophane (5-HTP, 200 mg) combined with carbidopa (CBD, 100 mg + 50 mg) exhibited dose-related neuroendocrine responsiveness and predictable pharmacokinetics. However, its applicability is limited by nausea and vomiting. A randomized, double-blind, placebo-controlled, four-way crossover trial was performed in 12 healthy male volunteers. The 5-HTP/CBD-challenge was combined with two oral anti-emetics (granisetron, 2… Expand
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