Enhanced tenascin expression associated with reactive astrocytes in human optic nerve heads with primary open angle glaucoma.

@article{Pena1999EnhancedTE,
  title={Enhanced tenascin expression associated with reactive astrocytes in human optic nerve heads with primary open angle glaucoma.},
  author={Janethe Deolina Oliviera Pena and H J Varela and Cynthia S Ricard and M. Rosario Hernandez},
  journal={Experimental eye research},
  year={1999},
  volume={68 1},
  pages={29-40}
}
Tenascin is a large extracellular matrix glycoprotein expressed in neural and non-neural tissues. In the central nervous system, tenascin is synthesized by astrocytes during development and wound healing, forming barriers and affecting neurite outgrowth. In this study we examined tenascin expression in optic nerve heads of normal and glaucomatous eyes and found that there is upregulation of tenascin mRNA and protein in reactive astrocytes from human glaucomatous optic nerve heads compared to… CONTINUE READING

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