Enhanced synthesis of stress proteins caused by hypoxia and relation to altered cell growth and metabolism.

@article{Heacock1990EnhancedSO,
  title={Enhanced synthesis of stress proteins caused by hypoxia and relation to altered cell growth and metabolism.},
  author={C. S. Heacock and Robert M. Sutherland},
  journal={British Journal of Cancer},
  year={1990},
  volume={62},
  pages={217 - 225}
}
Cultured cells maintained in very low oxygen levels alter their structure, metabolism and genetic expression. Culture conditions for cells were modified to minimise variation of nutrients and to allow normal survival levels after 24 h of hypoxic exposure. Under these hypoxic conditions, glucose consumption and lactate production rates were similar to aerobic rates until about 12 h after which the hypoxic rates increased. DNA and protein synthesis rates are continuously inhibited to about 48% or… CONTINUE READING

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