Enhanced sympathetic outflow and decreased baroreflex sensitivity are associated with intermittent hypoxia-induced systemic hypertension in conscious rats.

@article{Lai2006EnhancedSO,
  title={Enhanced sympathetic outflow and decreased baroreflex sensitivity are associated with intermittent hypoxia-induced systemic hypertension in conscious rats.},
  author={C J Lai and Cheryl C. H. Yang and Yuan-Yu Hsu and Ying Ni Lin and Terry B. J. Kuo},
  journal={Journal of applied physiology},
  year={2006},
  volume={100 6},
  pages={1974-82}
}
Long-term exposure to intermittent hypoxia (IH), such as that occurring in association with sleep apnea, may result in systemic hypertension; however, the time course changes in arterial pressure, autonomic functions, and baroreflex sensitivity are still unclear. We investigated the changes in cardiovascular neural regulations during the development of chronic IH-induced hypertension in rats. Sprague-Dawley rats were exposed to repetitive 1.25-min cycles (30 s of N2+45 s of 21% O2) of IH or… CONTINUE READING