Enhanced susceptibility to endotoxic shock and impaired STAT3 signaling in CD31-deficient mice.

@article{Carrithers2005EnhancedST,
  title={Enhanced susceptibility to endotoxic shock and impaired STAT3 signaling in CD31-deficient mice.},
  author={Michael D. Carrithers and Suman Tandon and S. Camalet-N. Canosa and Michael Michaud and Donnasue Graesser and Joseph A. Madri},
  journal={The American journal of pathology},
  year={2005},
  volume={166 1},
  pages={185-96}
}
Platelet endothelial cell adhesion molecule-1 (PECAM-1, CD31), an adhesion molecule expressed on hematopoietic and endothelial cells, mediates apoptosis, cell proliferation, and migration and maintains endothelial integrity in addition to its roles as a modulator of lymphocyte and platelet signaling and facilitator of neutrophil transmigration. Recent data suggest that CD31 functions as a scaffolding protein to regulate phosphorylation of the signal transducers and activators of transcription… CONTINUE READING

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