Enhanced susceptibility to MPTP neurotoxicity in magnesium-deficient C57BL/6N mice.

Abstract

We evaluated the effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in C57BL/6N mice fed a magnesium (Mg(2+))-deficient diet. On the 3rd week, Mg(2+)-deficient mice displayed increased anxiety- and depression-like behavior. In the Mg(2+)-deficient mice, a low does (10mg/kg) of MPTP treatment decreased dopamine (DA) and its metabolites contents in… (More)
DOI: 10.1016/j.neures.2008.09.009

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Cite this paper

@article{Muroyama2009EnhancedST, title={Enhanced susceptibility to MPTP neurotoxicity in magnesium-deficient C57BL/6N mice.}, author={Akiko Muroyama and Makiko Inaka and Hiroaki Matsushima and Haruhiko Sugino and Yoshinori Marunaka and Yasuhide Mitsumoto}, journal={Neuroscience research}, year={2009}, volume={63 1}, pages={72-5} }