Enhanced susceptibility for acquired torsade de pointes arrhythmias in the dog with chronic, complete AV block is related to cardiac hypertrophy and electrical remodeling.

@article{Vos1998EnhancedSF,
  title={Enhanced susceptibility for acquired torsade de pointes arrhythmias in the dog with chronic, complete AV block is related to cardiac hypertrophy and electrical remodeling.},
  author={Marc A. Vos and S H Marieke De Groot and S. Cora Verduyn and J van der Zande and H D Leunissen and Jack P. M. Cleutjens and M W T van Bilsen and M J A P Daemen and Jan J. Schreuder and M. A. Allessie and Hein J. J. Wellens},
  journal={Circulation},
  year={1998},
  volume={98 11},
  pages={1125-35}
}
BACKGROUND Chronic, complete AV block (CAVB) in the dog leads to ventricular hypertrophy, which has been described as an independent risk factor for arrhythmias. In this model, we examined (1) whether the short- and long-term electrical adaptations predispose to acquired torsade de pointes arrhythmias (TdP) and (2) the nature of the structural and functional adaptations involved. METHODS AND RESULTS We determined (1) endocardial right (RV) and left (LV) ventricular APD, DeltaAPD (LV APD-RV… CONTINUE READING
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4 Excerpts

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