Enhanced survival of neural cells embedded in hydrogels composed of collagen and laminin-derived cell adhesive peptide.

@article{Hiraoka2009EnhancedSO,
  title={Enhanced survival of neural cells embedded in hydrogels composed of collagen and laminin-derived cell adhesive peptide.},
  author={Makiko Hiraoka and Koichi Kato and Tadashi Nakaji-Hirabayashi and Hiroji Iwata},
  journal={Bioconjugate chemistry},
  year={2009},
  volume={20 5},
  pages={
          976-83
        }
}
To develop biomaterials that serve to improve the survival of neural cells transplanted into central nervous tissues, type I collagen-based hydrogels were prepared as a cell carrier. The hydrogels were modified with a laminin-derived peptide that is known to have an affinity for alpha3beta1 integrin, to transduce antiapoptotic signaling in embedded cells. For the modification of collagen, the peptide was fused to the N- or C-terminus, or both termini of a collagen-binding polypeptide domain by… CONTINUE READING
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