Enhanced survival of lung granulocytes in an animal model of asthma: evidence for a role of GM-CSF activated STAT5 signalling pathway.

@article{Turlej2001EnhancedSO,
  title={Enhanced survival of lung granulocytes in an animal model of asthma: evidence for a role of GM-CSF activated STAT5 signalling pathway.},
  author={R K Turlej and Laurence Fi{\'e}vez and Charlotte Sandersen and Sophie Dogn{\'e} and Nathalie A Kirschvink and Pierre M Lekeux and Fabrice Bureau},
  journal={Thorax},
  year={2001},
  volume={56 9},
  pages={696-702}
}
BACKGROUND As granulocyte/macrophage colony stimulating factor (GM-CSF) mediated delay of granulocyte apoptosis contributes to the accumulation of inflammatory cells at the site of inflammation in many diseases, we sought to determine whether asthma is also associated with a GM-CSF dependent increase in lung granulocyte survival. Moreover, because GM-CSF mediates its effects through activation of signal transducer and activator of transcription 5 (STAT5), we also investigated the potential role… CONTINUE READING