Enhanced survival effect of pyruvate correlates MAPK and NF-kappaB activation in hydrogen peroxide-treated human endothelial cells.

@article{Lee2004EnhancedSE,
  title={Enhanced survival effect of pyruvate correlates MAPK and NF-kappaB activation in hydrogen peroxide-treated human endothelial cells.},
  author={Yong-Jin Lee and I G Kang and Rolf B{\"u}nger and Young-Hee Kang},
  journal={Journal of applied physiology},
  year={2004},
  volume={96 2},
  pages={793-801; discussion 792}
}
We recently reported that pyruvate inhibited translocation and activation of p53 caused by DNA damage due to oxidant injury (Lee YJ, Kang IJ, Bünger R, and Kang YH. Microvasc Res 66: 91-101, 2003); this was associated with increased expression of apoptosis-related bcl-2 and decreased expression of bax gene. This study attempted to delineate possible regulatory sites and mechanisms of antiapoptotic pyruvate, focusing on reactive oxygen species-mediated signaling in a human umbilical vein… CONTINUE READING
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